Posted by KaraS on September 25, 2005, at 20:22:23
In reply to Re: 5 htp vs. sam-e » KaraS, posted by Ktemene on September 25, 2005, at 13:39:06
> > ... since for many people the antidepressant effect does not kick in until the 1600 mg per day level.
> >
> >
> > I had never heard that. I tried SAM-e and got up to 1200 mg. per day. I figured that since I didn't feel anything at all after several weeks at that level, that it just wasn't going to work for me. Maybe I shouldn't have thrown in the towel so quickly.
> >
>
> Hi Kara,
>
> I am using 1600mg per day because several of the clinical trials happened to use that dosage. But the sad truth is that even 1600mg may not be enough. I have copied below a post of Dr. Kramer on SAMe in which he says that more than 16 grams a day may be required! Part of the problem with SAMe is the exceedingly low bioavailability of the oral version. (A lot of the clinical trials with positive results used injected SAMe.) For that reason I think it is worthwhile to try to get the kind of SAMe that such evidence as there is suggests is the most bioavailable kind. As it happens, I was able to find a source for that kind that also was among the cheapest. But it still costs a lot! Oh well...
>
> Ktemene
>
>
> URL: http://www.dr-bob.org/babble/20020327/msgs/101374.html
> Re: Kramer: SAMe and omega-3
>
> Posted by Dr. Kramer on April 1, 2002, at 21:26:36
>
> In reply to Kramer: SAMe and omega-3, posted by Anyuser on April 1, 2002, at 9:56:57
>
>
> I like both SAM-e and Omega-e fatty acids because they work. The dosage of Omega-3 is less clear to me, but SAM-e, for most people, requires 1200-16600 mg/day.
Wow, 16+ grams a day! Who could afford that? I tried SAM-e a few years ago and used one of the best brands (Nature Made?) that at the time contained the most bioavailable form. I guess my trial wasn't complete though because of the dosage I used. Someday maybe I'll be able to afford to try more of it or maybe there'll be a better delivery system.Thanks for the information.
Kara
poster:KaraS
thread:558676
URL: http://www.dr-bob.org/babble/alter/20050924/msgs/559592.html