Posted by Chairman_MAO on May 5, 2005, at 19:24:06
In reply to Can GABA replace Clonazapam, posted by Maxime on April 30, 2005, at 16:11:49
If you can tolerate it, Depakote is a great drug to use during benzodiazepine withdrawal, as it is a:
1) Na+ blocker. Guards against convulsions, stabilizes mood.
2) GAD inducer: increases GABA synthesis
3) SSADH inhbitor (I think): increases GABA levels by slowing gaba catabolism
4) I think it also may be a GABA-T inhibitor at high doses due to a secondary effect that's a result of the SSADH inhibitionTrileptal or Tegretol are also good for benzo tapering. If you want to go the natural/alternative route, high doses of gastrodin + kava extract + phenibut + l-theanine together along with 25-50mg picamilon tid would help.
Also, most people do not know this, but vanillin (the chemical used in artifical vanilla flavoring) is a GABA-T inhibitor. I believe around 3g/day in divided doses can provide a decent effect in man. Never really tried it, just read some references to it.
And speaking of GABAnergics in disguise, the active ingredient in LISTERINE (thymol) is a positive GABA-A modulator (or direct GABA-A agonist, I forget which). I wonder if any gets absorbed buccally/sublingually when rinsing with listerine; that could account for some of the "addictiveness" of mouthwash.
poster:Chairman_MAO
thread:491982
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/494207.html