Posted by jujube on December 18, 2004, at 10:06:09
In reply to speculations on acetylcholine and NE, posted by zeugma on December 16, 2004, at 20:31:11
> Thanks for the links about DMAE.
Tamara,
>
> Thanks for the links about DMAE.-- My pleasure, although I am sorry I had not taken the time to include them in my direct response to you when I raised DMAE. My apologies.
> I do not believe the explanation that its manufacturers dropped DMAE from FDA approval for treatment of ADHD because of expense of clinical trials.
-- You are probably right. Not only am I not the hottest coal in the fire at times, I am, by nature (unfortunately), quite gullible (although I always told those who made fun of my gullible nature that I was actually trusting and that was a good thing). I found another article that talks about DMAE, and what was said was that DMAE was originally marketed as a prescription drug for hyperactivity, but was withdrawn because it lacked significant efficacy evidence. The article also talks about the some types of ADHD appearing to be mediated by dopamine-hypometabolism and others may be due to acetylcholine dysfunction. Here is the website, if you are interested:
http://www.nutraceuticalsworld.com/Sept011.htm
> Interestingly, nortriptyline, which I use to treat this problem (believe me, it is a TERRIBLE problem, as I simply cannot remain in a 'mixed' consciousness for very long- it literally feels like two forms of consciousness fighting for control of my CNS, and can be extremely painful as well as jarring) is a cholinergic antagonist, and this underlies some of its effectiveness in treating both depression and narcolepsy. It is also somewhat effective in treating ADHD (in fact I was prescribed it as a second-line treatment for ADHD). Clomipramine (but not Celexa) is also somewhat effective for ADHD. Clomipramine increases noradrenergic neurotransmission, and this causes indirect reduction of cholinergic neurotransmission. Norepinephrine and acetylcholine are 'opposite numbers' in the CNS (experts here are invited to evaluate this statement!).
-- I can only begin to imagine what you go through each day, and my heart goes out to you. I certainly do not suffer that greatly. I am extremely hyper and have the attention span of a tse tse fly, but these things have not caused any signficant problems in my life. The jobs I have had have always been good for a hyper person, and even the distractability and short attention span have not been too problematice since my work has always required me to deal with many multiple priorties over the courseof any given day. However, the attention span issue does become a bit of an issue when I have to read long court decisions or review and analyze long, tedious pieces of draft legislation, or sit in a long meeting.
Anyways, take good care, and I hope I'll be chatting with you again soon.
Tamara
poster:jujube
thread:430543
URL: http://www.dr-bob.org/babble/alter/20041212/msgs/431208.html