Posted by Larry Hoover on October 29, 2004, at 9:11:55
In reply to Re: dopamine oxidation » raybakes, posted by raybakes on October 21, 2004, at 5:04:44
> Hi Lar,
>
> found some more info on dopamine metabolism - find NADPH quinone oxidoreductase (NQO) of interest. From what I can make out, it seems that NQO reduces quinones to make them available for detoxification via sulphation or glucuronidation. One abstract talked about copper complexing with dopamine and inducing a neurotoxic reaction - NQO, inhibited this too.I once saw the most amazing "map" of all the reactions/pathways that tyrosine went through. I think it was tyrosine.....anyway, I think there were something like 800 products, intermediates, etc.
One can focus too much on a single tree, and forget that one is in a forest at all.
My "takehome message", the component in these articles that most catches my attention, is the link to the neuroprotective effects of those workhorse antioxidant systems. They have a limited capacity, a threshold of capability, beyond which neurotoxic effects can proceed unhindered.
The core dysfunction in numerous disorders, symptom clusters that differ in expression in different people, is oxidative stress. Antioxidants are sacrificial. They quench a highly reactive species by laying down their lives to protect the lives of others (in a personified expression). They consume chemical bullets by getting between the gun and the innocent target. What goes wrong when a bullet hits the target is illustrative of why we need to ensure a depth of reserve combatants. We preclude the need to examine the sequelae if we block the bullet before it reaches the target.
Lar
poster:Larry Hoover
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/408713.html