Posted by Larry Hoover on November 4, 2003, at 9:27:04
In reply to Glad I asked that question, then ;-) (nm) » Larry Hoover, posted by DSCH on November 3, 2003, at 17:57:38
Valine also uses the same transporter, so there are six, not five, competitors. Gabapentin and other drugs will compete for it, as well.
Anyway, leucine and isoleucine seem to serve structural roles in specialized proteins, and modulate the activity of receptors such as GABA(A) and GABA(B), NMDA, and NA.
Most people have no problem getting an adequate supply of these aminos, but disturbances in proportions of these six aminos are associated with certain pathologies....Alzheimer's, schizophrenia, mania, depression, OCD.
It's hard to get a clear picture of what leucine and isoleucine do.
Lar
poster:Larry Hoover
thread:275292
URL: http://www.dr-bob.org/babble/alter/20031104/msgs/276448.html