Posted by Cam W. on August 30, 2001, at 1:33:19
In reply to Re: SalArmy4me Present 4 Duty: Servant, citizenSOL » SalArmy4me, posted by Zo on August 30, 2001, at 1:06:20
Zo - If he took the tryptophan (2g) with the moclobemide (1600mg or so), he could be in serious trouble (ie. there is a risk of serotonin syndrome).
His post where he recommends Ludiomil (maprotiline) was a badly designed study. It is funny that he missed that; because under the abstract he recopied a letter to the editor that, point by point, showed the glaring errors in the study design that, an in essence, invalidated the study. It was as if he didn't read what he had pasted.
He then came back saying that there was much evidence of maprotiline efficacy. Clinically, the drug really on works in only a small subgroup of depressed people. Caution must also be used in those who have heart disease and diabetes. Jason never mentioned any of this.
I have noticed a change in him ever since he started the moclobemide. Ordinarily, moclobemide does not cause many CNS side effects (ie. mania, mood disturbance) unless taken with sympathomimetic drugs (esp. cocaine or amphetamines). He may be wise to have his blood pressure checked.
The minor delusions of grandeur (if that's what they are, possibly, hypomania?) are reminiscent of the onset of psychotic episode (as could be the religious component of his latest posts). I cannot be sure of this, though; as these symptoms can be from a drug-drug interaction, as well.
Jason should see a doctor, and since he doesn't listen to any of us, perhaps using the Sally Ann (a group he trusts) may be the way to get him the help he needs.
Sincerely, Cam
poster:Cam W.
thread:1835
URL: http://www.dr-bob.org/babble/admin/20010718/msgs/1851.html