Posted by deniseuk190466 on January 29, 2024, at 6:03:24
In reply to Re: Where would you be without my meds » deniseuk190466, posted by SLS on January 22, 2024, at 22:27:49
Hi Scott,
I was doing well but then I asked to be switched from Seroxat to Prozac and then the extreme anxiety started again. Luckily the Zyprexa does help with that. Back on the Seroxat now and feeling better.
Are you saying that people with the most severe depression are more likely to have a placebo response or less likely? I don't know what is wrong with me any more but I know for a fact that I've never had a placebo response to anything related to my mood. You could say "well how would you know? if your response is placebo or not?" but I have tried so many other things over the years, Ketamine, ECT, TMS, health supplements, homeopathy and I Zilch, nothing, I could not detect any improvement in mood. Whereas with Seroxat and Zyprexa, Lyrica, Klonopin, I KNOW they help with my mood and it is nothing to do with placebo. I don't think my depression is severe in the sense that when I am at my worst I am able to get out of bed and function to a certain degree.
It is awful though if the placebo affect is skewing the data. To be honest I am not sure how a person with depression could have a placebo response. Afterall, when you are depressed your thinking is totally negative so you don't expect to feel better. Thats the whole point. To get a placebo response there has to be a certain degree of positive thinking involved. I know having people pay you attention and take an interest can be helpful but I would expect the patient would still know whether it is the actual treatment that is helping or just the situation itself is helping.
I'm going to look up why placebo response is higher these days than it used to be as it is interesting.
I am really glad to see that you are doing well and it's lovely that you are still on this board, helping people. I know that your struggle with biopolar has been far greater than mine.
I have been very fortunate with meds. Although I have never understood why my reaction to SSRIs was totally different in my late 30s to how it was in my 20s, I still was fortunate enough so that by the time I got really bad, they knew about Zyprexa and how that helps with anxiety.
Denise
poster:deniseuk190466
thread:1122302
URL: http://www.dr-bob.org/babble/20230117/msgs/1122313.html