Posted by undopaminergic on August 16, 2023, at 10:37:36
In reply to Re: Partial response to vortioxetine (Brintellix) » undopaminergic, posted by SLS on August 16, 2023, at 8:44:11
> Hi, UD.
>Hi, SLS.
> An ultimately successful treatment often starts with a brief improvement during the first two weeks (often within 7 days), only to disappear. However, my doctors at the NIH told me that this is considered by them to be a "blip improvement", and predictive of eventual success.
>Yes. I had the blips early on, and they were transient. Now, months later, I'm responding more substantially. This second "batch" of reactions came soon after a dose increase, so with an earlier dose elevation I might well have responded much sooner.
> Unless you feel worse or have intolerable side-effects that don't mitigate over time, it is worth sticking with it - at least for 6 weeks.
>I've been on it since 9 Dec 2022, although I started at only 5 mg/day.
> Vortioxetine, as I'm sure you are aware, hits almost every serotonin receptor, some as an agonist and some as an antagonist. Initially, researchers were focused on 5-HT7 receptors. I don't know if the consensus on this has changed.
>The 5-HT7 receptor blockade, on its own, does not produce much of an effect. I know this because I tried lurasidone (Latuda).
I'm less certain about 5-HT3 blockade. I think it may have been involved in my early reactions to vortioxetine.
> I don't know if you believe that prayer serves any purpose, but I prayed for you anyway.
>Thank you.
> The best of luck!
>And thank you!
-undopaminergic
poster:undopaminergic
thread:1122171
URL: http://www.dr-bob.org/babble/20230117/msgs/1122176.html