Posted by SLS on March 17, 2023, at 10:37:42
In reply to to sls again, posted by rose45 on March 16, 2023, at 15:22:03
Hi, Rose.
Let me know how you are doing. I posted another message to you just above this one:
http://www.dr-bob.org/babble/20230117/msgs/1121923.html
Please let me know how your outlook has changed after reading it.
I think your first job is to think of ways to navigate the NHS regulations. You will need to find a doctor willing to prescribe Nardil in combination with other drugs, especially TCAs. For me, I absolutely do not respond well to any treatment unless it combines MAOI + TCA. You would want to limit your selection of TCAs to nortriptyline, desipramine, amitriptyline, and doxepin. Trimipramine might be okay, too, but I don't know of anyone who has tried it combination with a MAOI. However, the drugs that you absolutely must avoid when taking a MAOI are ANY that include as one of its properties, serotonin (5-HT) reuptake inhibition.
Examples:
SSRI
SNRI
imipramine
clomipramine
vortioxetine
vilazodone
trazodone
milnacipran
Levomilnacipran
5-HT receptor agonists?* Fenfluramine (FINTEPLA) has been used for weight-loss, but was taken off the market because it caused heart valvulopathy (damage to heart valves). This is not due to serotonin receptor agonism (stimulation). Instead, it is caused by 5-HT2B receptor antagonism (blocking).
* The most dangerous drugs to combine with MAOIs are 5-HT reuptake inhibitors. Serotonin Syndrome is often the result. The only drug I know of that can be used as a remedy for Serotonin Syndrome is cyproheptadine (Periactin). There may be others.
If you haven't tried lithium at dosages above 150 mg/day, you absolutely must try 300-450 mg/day.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1121922
URL: http://www.dr-bob.org/babble/20230117/msgs/1121924.html