Posted by SLS on March 14, 2023, at 23:05:20
In reply to Re: maoi poop out » SLS, posted by rose45 on March 13, 2023, at 10:52:49
Hi, Rose.
I forgot to provide the list of drugs I've taken over the last 40 years. I began my ascent to remission about 1/2 years ago. In those 40 years, I had only 6 months of respite when I responded to Parnate 60 mg/day + desipramine 150 mg/day. Even those 6 months weren't a 100% improvement. However, I became manic after the 6 months, and my doctor had me stop both medications. When I relapsed 1 month later, he decided to play with Prozac, which had just been approved. It didn't work, but he refused to put me back on what did work - even if too well. But that was standard operating procedure in 1987. With 20/20 hindsight, it might have been better to have left me on the combo, but add lithium + clonazepam (Klonopin) to put a lid on the mania. I'll have to wait until tomorrow to write more.
F*ck it. Please don't tell my fiancee that I was up at midnight.
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My knee-jerk reaction is that you should switch to Nardil, and titrate it VERY gradually.The second wave of psychopharmacologists (1980s) discovered a strategy for people who relapse on Nardil, even after years of remission. They learned that if you discontinue Nardil for 3 months, and then restart it, you can see it work again.
Example:
7.5 mg/day (1/2 pill) for 1-2 weeks.
15 mg/day for another 2 weeks.
30 mg/day for 3 weeks.
45 mg/day for 3 weeks.
60 mg/day for 3-5 weeks.
75 mg/day for 3-5 weeks
90 mg/day if necessary.With Nardil, it can take 3 months to receive a big-time response to it.
Question: How long should you wait from the time you take your last Parnate pill to when you take your first Nardil pill?Answer: 10-14 days.
What we have done here is to use our best guesses about *clinical* psychiatry. No knowledge or theories about neurotransmitters and receptors are necessary to get well.* I have been on Nardil at least 10 times. I *always* suffered side-effects, especially dizziness and the inability to urinate. I would spend 30-45 minutes sitting on the toilet to get it to happen. The alternative was to get catheterized every time I needed to take a piss. This time, I played out a hunch. I thought that if don't *trigger* the side-effects in the first place, you might not get them. So, I decided to try titrating very slowly - similar to the schedule I provided. I think it's worth a try. Unfortunately, clinical reactions to the same drug can be opposite when taken by two individuals, so I can't make any guarantees.
Then, you and your doctor can experiment with lithium and/or certain atypical antipsychotics. I do not glean a robust response to a treatment regime unless it contains a combination of MAOI and tricyclic (TCA) - desipramine, nortryptyline, doxepin, and perhaps trimipramine are usually safe to combine with Parnate or Nardil. Supposedly, you are supposed to start the tricyclic first, but I have combined them both ways. For me, the order doesn't matter.
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This is the list I forgot to include in my earlier post to you:* This list includes drugs used as remedies for side effects, mostly for sleep and anxiety.
Total = 81
Adinazolam
Agomelatine
Alprazolam
Amitriptyline
Amoxapine
Amphetamine
Aripiprazole
Asenapine
Bromocriptine
Bupropion
Carbamazepine
Chloral Hydrate
Chlorpromazine
Clomipramine
Clonazepam
Clorgyline
Desipramine
Desvenlafaxine
Dexmethylphenidate
Donepezil
Doxycycline
Duloxetine
Escitalopram
Fluoxetine
Fluphenazine
Gabapentin
Idazoxan
Iloperidone
Imipramine
Indalpine
Isocarboxezid
Ketamine
Lamotrigine
Levitiracetam
Lithium
Lorazepam
Lurasidone
Memantine
Methylfolate
Methylphenadate
Mifepristone
Milnacipran
Minocycline
Mirtazapine
Moclobemide
Modafinil
Naltrexone (LDN)
Nomifensine
Nortriptyline
Olanzapine
Oxcarbazepine
Paroxetine
Pemoline
Perphenazine
Phenelzine
Prazosin
Pregabalin
Protriptyline
Quetiapine
Reboxetine
Risperidone
Selegiline
Sulpiride
Temazepam
Thioridazine
Thyroxine T4
Topiramate
Tranylcypromine
Trazodone
Triazolam
Triiodothyronine T3
Trimipramine
Valproate
Venlafaxine
Vilazodone
Viqualine
Vortioxetine
Zaleplon
Ziprasidone
Zolpidem
ZonisamideOf course, my treatment over the last 40 years included innumerable combinations of these drugs.
I haven't proofread this - not that proofreading ever helps me.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1121897
URL: http://www.dr-bob.org/babble/20230117/msgs/1121914.html