Posted by Lamdage22 on February 22, 2023, at 10:19:06
In reply to Re: Is Cyplyta a reasonably strong antipsychotic?, posted by undopaminergic on February 22, 2023, at 3:22:43
> > > Do you find that your psychotic symptoms start to come back if you lower the dose? Do you notice a difference if you forget a dose?
> >
> > Not exactly, but I can't sleep if I lower the dose. However, I haven't done it in a long time.
> >
> > The forgotten dose usually leads to not being able to sleep.
> >
> >
>
> Not being able to sleep is a problem, for sure, but in my opinion it is not best remediated with antipsychotics. Can you try cyproheptadine (Periactin)? It is both an antihistamine (histamine H1-receptor antagonist) and a serotonin 5-HT2A receptor antagonist. If that doesn't work, and the dopamine antagonism turns out essential, try augmenting with a low dose of a more selective dopamine antagonist (than olanzapine and quetiapine) like haloperidol; in this situation, I would avoid sulpiride and amisulpride, as they can have stimulant effects. There are also other agents that can help with sleep, such as clonidine and Xyrem. And what about the Z-drugs ((es)zopiclone, zolpidem, zaleplon)?
>
> -undopaminergicIm kind of putting the psychiatric things on hold and figuring out what is going on with me. I think something is. My tryptase level was 200% higher than upper end of the reference. So that seems more pressing now.
Seroquel 750mg
Zyprexa 17.5mg
Lithium 225mg
Trazodone 75mg
Metformin 2000mg
Orthomolecular
poster:Lamdage22
thread:1121832
URL: http://www.dr-bob.org/babble/20230117/msgs/1121843.html