Posted by undopaminergic on February 5, 2023, at 16:15:47
In reply to Re: Are Neuroleptics brain specific anticholinergics? » Lamdage22, posted by SLS on February 5, 2023, at 11:17:10
> Hi.
>
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> I agree with UD.
>
> I wonder, though, if the BBB barrier prevents some substances from exiting the brain that it had previously allowed to enter it. If this occurs, then I imagine the concentration of a drug in the brain becomes higher than that in the rest of the body. Could be.
>I can't clarify your question about the BBB possibly retaining substances. However, another mechanism for accumulation of a substance in the brain is if the substance is lipophilic, in which case the concentrations will be higher in the brain (and other fatty tissues) than the bloodstream.
-undopaminergic
poster:undopaminergic
thread:1121718
URL: http://www.dr-bob.org/babble/20230117/msgs/1121735.html