Posted by iforgotmypassword on December 7, 2022, at 15:57:19
In reply to Mice lacking 5-ht2c unlearn fear faster, posted by linkadge on December 5, 2022, at 14:04:27
What i recall from reading abt this recently given 5-ht2c seems to b the disaster receptor responsibile for ssri akathisia, bruxism etc that chokes DA efflux from VTA:
-forget risperidoneits actually pretty weak. U need higher 2c affinity than 2a to get significant occupancy at 2c receptors, and saturation with inverse agonism seems to b required to get the pro-DA anti-EPS effect you see in animal models; risperidone is also one of the harshest antipsychotics ive ever taken on movement
-this leaves clozapine, mirtazapine, and maybe asenapine and sertindole but i doubt they are as gentle on movement as clozapine
poster:iforgotmypassword
thread:1121215
URL: http://www.dr-bob.org/babble/20220917/msgs/1121227.html