Posted by beckett2 on August 24, 2022, at 16:14:12
In reply to I should learn how to proofread better. » beckett2, posted by SLS on August 22, 2022, at 19:16:33
> What I was trying to say is that the antidepressant response you experience is, on an extremely simplistic level, counterintuitive when considering the recent work with lithium and glutamate activity. That work reports a bimodal action of lithium on glutamate activity based upon dosage. At low dosages, lithium promotes an increase in glutamate activity. At higher dosage, lithium reduces glutamate activity. Glutamate is the most ubiquitous excitatory neurotransmitter. At lower dosages, lithium can have an antidepressant effect, but not an antimanic effect.
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> So, the question is, why do the actions of lamotrigine and ketamine to reduce glutamate activity produce an antidepressant effect when the low dosages of lithium known to exert an antidepressant effect increase glutamate activity.
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> Man's models of how the brain works are full of contradictions. Of course, the workings of the brain has no real contradictions. It knows very well how it works.
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> I think your combining lamotrigine and ketamine is a great idea.
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>
> - Scott
>I really don't know. Lithium was not a good medication for me. The suicidal ideations were gone, which is remarkable, but my depression was almost as bad. Plus I have a twitch in one thumb to this day.
My understanding is Ketamine is a dirty drug. Is it? Also, I'm likely in a subset of people who had bipolar depression and fibromyalgia onset together. Interestingly, a recent study observed people with a history of childhood trauma responded more robustly.
I take troches (lozenges) at home. About what, 30-40% have no response? Also, yes, I have mild dissociation. On good days, it's very pleasant.
I hope you're still doing well. No matter the treatment, it's always a struggle to some degree. Speaking for myself at least.
like a bird on a wire
poster:beckett2
thread:1120378
URL: http://www.dr-bob.org/babble/20220530/msgs/1120477.html