Posted by linkadge on August 1, 2022, at 16:07:06
In reply to Re: serotonin theory of depression torpedoed, posted by Jay2112 on July 30, 2022, at 18:33:08
Here is food for thought...
In mice lacking the presynaptic serotonin autoreceptor, the anti-anxiety effects of SSRIs are absent.
The presynaptic receptor (when activated by serotonin) slows further serotonin release.
So, some of the mechanism for SSRIs may be a result of 'regulating' serotonin rather than simply raising it.
It is similar with methylphenidate. It can (believe it or not) reduce dopamine levels in ADHD models.
Linkadge
poster:linkadge
thread:1120172
URL: http://www.dr-bob.org/babble/20220530/msgs/1120194.html