Posted by Jay2112 on April 3, 2022, at 20:46:46
In reply to Re: Combining Prozac and Paxil.... » Jay2112, posted by SLS on April 3, 2022, at 19:42:52
> > > People don't do this. Why? Spinning off the 2 MAOIs at once thread...but....
> >
> > Well, it is actually showing up in the research.
> > https://pubmed.ncbi.nlm.nih.gov/34728290/
> > This is with youth, but just type in combine ssri pubmed in google, and you will find a whole span.
> >
> > My take, from actually combining Paxil and Prozac, was that is was good...to a point. Paxil has a mellowing anticholinergic action (not as strong, but similar to Elavil (Amitriptyline). Prozac also works on norepinephrine, and GABA. So...with a small dose of Paxil (5mg) and a regular dose of Prozac (20mg), I was able to get a bit more of a calming effect. But, the caveat, is that for some reason (maybe because of Paxil's stronger effect on serotonin) I developed some severe akathisia...inner restlessness. BUT, this was 15 or so years ago, and my dose of Prozac may have been much higher and/or the Paxil dose was higher.
> > It also could have been serotonin syndrome, so you do have to be careful. But, this is not unconventional territory.
> >
> > Best,
> > Jay
> >
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> I think the title of the paper you cited is confusing. What the paper is about is combining one SSRI with cognitive-behavioral therapy. I may have missed something, though.
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> - ScottOppps...sorry. I had bookmarked a few studies with SRI/SRI combos, but now when I need them, I can't find them..urrgghh..lol. Yes, the study I referenced was a CBT/SRI study.
But, my personal, subjective experience is only n=1, but I swear, I came across a few studies talking about both SRI/SRI and SNRI/SRI combos. One in particular, citalopram and venlafaxine, eased me right out of a horrid mixed episode.
Sorry...
Jay
Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-
poster:Jay2112
thread:1119194
URL: http://www.dr-bob.org/babble/20220128/msgs/1119258.html