Posted by SLS on March 8, 2022, at 20:35:01
In reply to Pindolol may improve antidepressant action, posted by Lamdage22 on March 8, 2022, at 10:54:40
> https://pubmed.ncbi.nlm.nih.gov/11339972/
>
> I researched it because I was thinking of short acting beta blockers that may or may not get me to sleep easier after intense exercise.In the 1990s, pindolol was reported to "hasten" the response to standard antidepressants (not increase the statistical response rate). The explanation at the time was that in addition to blocking adrenergic beta receptors, it also agonized (stimulated) 5-HT(1A) receptors, which I believe act as an inhibitory autoreceptor along serotonin axons. Pindolol tends to "mute" and interrupt the signal (action potential) carried down the axons of these neurons. Using pindolol as an augmenter of antidepressants didn't catch on back then.
However...
https://pubmed.ncbi.nlm.nih.gov/10727715/
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1118925
URL: http://www.dr-bob.org/babble/20220128/msgs/1118937.html