Posted by undopaminergic on February 15, 2022, at 5:35:27
In reply to The Ritalin Vs. Dexedrine debate, and more..., posted by Jay2112 on February 14, 2022, at 17:31:28
> Ritalin just seemed way to strong for me, even at smaller doses.
>That is peculiar, because Dexedrine is (dose-dependently) much stronger than Ritalin. Ritalin is just a reuptake inhibitor, while Dexedrine is a releaser. If I recall correctly, a reuptake inhibitor (in the studies I read it was cocaine) can increase synaptic dopamine up to 175% or so of baseline in the nucleus accumbens, whereas amphetamines can achieve several hundred percent.
While I have forgotten the precise figures, the point remains that amphetamines elevate dopamine more than reuptake inhibitors.
Of course, it is still true that you feel a stronger effect, but it is likely not due to higher dopamine elevation.
-undopaminergic
poster:undopaminergic
thread:1118605
URL: http://www.dr-bob.org/babble/20220128/msgs/1118610.html