Posted by undopaminergic on October 11, 2021, at 9:45:01
In reply to Re: Ritalin + an MAOi = Greater baseline D/NE? » PeterMartin, posted by linkadge on October 8, 2021, at 15:49:26
> Of course, I don't know for sure. Sometimes strange things happen when multiple pathways of neurotransmitter are inhibited. For example, in some animal models of DAT + COMT + MAO inhibition, dopamine levels are significantly reduced vs. normal animals.
>Are these gene knockouts or are the inhibitions produced in normal animals through drugs?
> Some of this is likely the result of early life modifications in neurotransmission. Also, there are the autoreceptors which slow monoamine firing when synaptic levels become too elevated.
>This can be counteracted with sulpiride or its workalikes.
-undopaminergic
poster:undopaminergic
thread:1117157
URL: http://www.dr-bob.org/babble/20210723/msgs/1117233.html