Posted by undopaminergic on September 6, 2021, at 3:49:39
In reply to Re: My Disappointment here + My early years » undopaminergic, posted by Jay2112 on September 5, 2021, at 19:27:00
> >
> > If so, I have to ask why memantine, a NMDA-glutamate receptor antagonist, can induce mania for me?
> >
> > -undopaminergic
> >
>
> Hi U-D:
>
> I believe memantine is closely related to amantadine?Yes, memantine is dimethyl-amantadine.
> Amantadine is a dopamine agonist, so memantine may share some of amantadine's dopamine agonism, which of course will send you orbiting.
>I'm my view, amantadine is also a NMDA-glutamate antagonist, but weaker than memantine. I don't agree that amantadine is any kind of serious dopamine-reuptake inhibitor, which one study claims it is. It is only *functionally* a dopamine agonist, by means of the NMDA-inhbitory action.
-undopaminergic
poster:undopaminergic
thread:1116650
URL: http://www.dr-bob.org/babble/20210723/msgs/1116845.html