Posted by SLS on August 22, 2021, at 4:07:56
In reply to Re: Abilify for Erectile Dysfunction? » Jay2112, posted by undopaminergic on August 21, 2021, at 12:03:54
> > >> I wonder why you'd need Abilify as a dopamine *agonist* when you are already taking one in the form of bromocriptine?
With amisulpride, the variability of the net effect on dopamine activity is established by the ratio of presysnaptic occupancy as a pure antagonist versus its occupancy on the postsynaptic receptors, also as a pure antagonist. If I remember correctly, presynaptic receptors have a higher binding affinity to dopamine than postsynaptic receptors. Amisulpride acts to stimulate more potently presynaptic receptors than postsynaptic receptors. This reinforces the negative feedback loop, and reduces the manufacture and release of dopamine. However, as the dosage of amisulpride is increased, the blocking of postsynaptic receptors by amisulpride becomes the driving therapeutic mechanism. The bottom line is that at low dosages, amisulpride has an antidepressant effect while high dosages have an antipsychotic effect.Amisulpride is probably the best antipsychotic to treat the negative symptoms of schizophrenia.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1116533
URL: http://www.dr-bob.org/babble/20210723/msgs/1116594.html