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Re: luvox vs other SSRI's

Posted by undopaminergic on July 24, 2021, at 12:35:23

In reply to Re: luvox vs other SSRI's, posted by linkadge on July 24, 2021, at 11:45:41

>
> As mentioned, luvox is a sigma-1 agonist. This activity has antidepressant / anti-OCD effects in its own right. MG per MG, escitalopram would be much more potent on the serotonin reuptake system than luvox.
>

Per unit (mg) of weight is not the only way to look at potency. The dose-response curve is probably more relevant than affinity. I don't have any data on how the different SSRIs compare in this regard, but I know paroxetine is considered the most potent, followed by sertraline. What I mean, is that it is possible to reach near 100% serotonin transporter inhibition with these drugs (without the need for megadoses), whereas this is not possible with drugs that have a flattening dose-response curve.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20210723/msgs/1116081.html