Re: I am reposting something I wrote to Linkadge.

Posted by linkadge on July 10, 2021, at 11:06:49

In reply to I am reposting something I wrote to Linkadge., posted by SLS on July 9, 2021, at 22:21:03

Yeah, parnate and nardil are powerful medications. Nardil, for example, metabolizes to PEA (amongst other things) and also inhibits MAO-B which slows the breakdown of PEA. If PEA gets too elevated this can certainly lead to manic like behavior. The MAOIs are known for making even 'normal' people feel better (perhaps temporarily, however).
The SSRIs (or SNRIS) just seem to produce a superficial feeling of wellbeing. But, lately, it's not even wellbeing as much as it is just feeling numb. I did fairly well a few years back on nortriptyline and lithium (with a bit of tryptophan). However, my sleep started to become disjointed (microwakenings). When I switched back to mirtazapine, the sleep improved but the depression worsened.
I breifly took parnate (for about a month) but had a spontaneous hypertensive crisis and was yanked off of it. While I likely didn't have long enough for a full effect, the mood improvement I experienced was much more comprehensive than any SSRI.
MAOIS not only elevate the three primary monoamines, but also the trace amines which have antidepressant effects in their own right.
I am 'semi-functional' on drugs like effexor, mirtazapine, lithium and ritalin (which I am prescribed), but I'm definitely not well, and just feel like I am masking symptoms. I have a bit of time off this summer, so I decided to try the alternatives (as mentioned in my above post).
The PEA is powerful and more so when taken with rhodiola. I am not looking to get high or develop an addiction so, I am taking it in very measured amounts (dissolve in eyedropper and put a few drops under my tongue). In theory, sublingual might bypass some of the rapid destruction by MAO-B. See my picture.
https://drive.google.com/file/d/1-lfmyXq757gBaOAtU-gGEQakX4Of4FfY/view?usp=sharing
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I am reposting something I wrote to Linkadge. SLS 7/9/21
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Re: I am reposting something I wrote to Linkadge. » Lamdage22 SLS 7/15/21
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