Posted by linkadge on June 27, 2021, at 16:20:52
I know I've posted on this topic before, but there is a high occurrence of schizophrenia and psychostimulant abuse (particularly amphetamines).
The actions of amphetamine are complex (I don't understand it myself) but they do activate a receptor called TAAR1. Interestingly, TAAR1 activation can actually reduce hyperdopaminergic function (i.e. reduce dopamine). It is hypothesized that amphetamine may for for ADHD via TAAR1 activation.
https://www.pnas.org/content/108/20/8485
Amphetamine is typically seen to increase dopamine, but it does have this action which does the exact opposite. It is complex but interesting.
I am certainly not recommending the use of amphetamine for people with psychotic disorders, but more a thought experiment on exactly what is going on.
TAAR1 agonists actually have antispychotic effects. I wonder if some schizophrenic patients are actually feeling more of the TAAR1 agonist effect than normal people.
Linkadge
poster:linkadge
thread:1115668
URL: http://www.dr-bob.org/babble/20210418/msgs/1115668.html