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Re: SSRIs with atypical antipsychotics

Posted by linkadge on May 25, 2021, at 17:37:11

In reply to SSRIs with atypical antipsychotics, posted by undopaminergic on May 25, 2021, at 6:34:44

Yeah, it's probably an effect of interaction with 5-ht1a / 5-ht2ac receptors. Similar effects are noted with other atypicals (like olanzapine) or mirtazapine.

Of note though, the drug itself may block some of its own effect. For example, it may release dopamine, but then also block dopamine receptors (i.e. in the NAC) blocking some of the effect of this monoamine increase.

Last week, my sleep got really messed up again. I ended up taking a small dose of olanzapine and amitriptyline. I was surprised that my mood improved quite a bit over the next few days. I have a love hate relatinship with effexor. It really makes me flat.

Linkadge


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URL: http://www.dr-bob.org/babble/20210418/msgs/1115319.html