Posted by NKP on May 23, 2021, at 5:11:18
In reply to Re: Attn: Linkadge(?) Can you elaborate on this study? » undopaminergic, posted by linkadge on May 22, 2021, at 8:34:09
> I suppose it is a matter of dose, but the reason I say this is .....
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> At a similar of DAT inhibition, cocaine causes more dopamine release than ritalin. Some of this effect can be blocked by 5-ht1b receptor antagonists. When you add serotonin reuptake inhibition to ritalin, you get a greater degree of dopamine release, via stimulation of 5-ht1b receptors in the NAC. Cocaine is a triple reuptake inhibitor whereas ritalin does not have any effects on the serotonin transporter.
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> Also in studies on addiction related genes (i.e. intermediate early genes / cfos), you notice a much more significant activation with cocaine than ritalin. Interestingly, adding a serotonin reuptake inhibitor to ritalin produces a more 'cocaine like' profile in terms of activation of addiction pathways.
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> That being said, if you took a dose of ritalin that produced higher DAT inhibition, the effects could be more similar.
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> Linkadge
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>Does that mean that taking methylphenidate while on an SSRI might be more addictive than taking methylphenidate when not on an SSRI?
poster:NKP
thread:1115174
URL: http://www.dr-bob.org/babble/20210418/msgs/1115263.html