Re: lamictal

Posted by rjlockhart37 on April 9, 2021, at 14:14:15

In reply to Re: lamictal, posted by rjlockhart37 on April 6, 2021, at 0:22:10

I dug up some info
https://go.drugbank.com/drugs/DB00555
"
"Lamotrigine likely acts by inhibiting sodium currents by selective binding to the inactive sodium channel, suppressing the release of the excitatory amino acid, glutamate"
. "In laboratory binding assays, it demonstrates weak inhibitory effect on the serotonin 5-HT3 receptor. Lamotrigine also weakly binds to Adenosine, adrenergic receptors, dopamine D1/D2 receptors, GABA A/B receptors, histamine H1 receptors, κ-opioid receptor (KOR), mACh receptors and serotonin 5-HT2 receptors with an IC50>100 µM. Weak inhibitory effects were observed at sigma opioid receptors.14 An in vivo study revealed evidence that lamotrigine inhibits Cav2.3 (R-type) calcium currents"

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lamictal rjlockhart37 3/31/21
Re: lamictal rjlockhart37 4/1/21
Re: lamictal Lamdage22 4/2/21
Re: lamictal rjlockhart37 4/6/21
Re: lamictal rjlockhart37 4/9/21
Re: lamictal rjlockhart37 4/9/21
Re: lamictal rjlockhart37 4/10/21
Re: lamictal rjlockhart37 4/10/21
Re: lamictal Lamdage22 4/16/21
Re: lamictal undopaminergic 4/16/21
Re: lamictal Lamdage22 4/16/21

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