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Re: Irreversable MAOI + Buspirone, anyone? Petermartin

Posted by Psy-Naught on February 24, 2021, at 12:07:20

In reply to Re: Irreversable MAOI + Buspirone, anyone?, posted by Petermartin on February 24, 2021, at 1:18:48

I've been on it twice. Around 2007 I switched from phenelzine to isocarboxazid. It works but, at least for myself (and I've heard this elsewhere) the 60mg max dose is hardly enough! Last time I went up to 150mg without any problems. That was together with clonazepam, bupropion and various other tral & error addons. Taken in one dose, am.
About 2015 I gave phenelzine a go. Never got that 'awakening' feeling back which I got the 1st time round and which lasted at least 5 years but slowly gave me more and more lethargy near the end.
Then, 2018 (I think) it went out of stock completely. That's what happens when you rely on China as your sole supply source... I actuall wanted off it anyway but my doctor wanted to persist.
Fast forward - the dose increase has been done much slower this time round, mainly because this time round I'm taking psychostims. I don't know why my doc is so cautios really. I was at 120mg of phenelzine before I switched.
But when I hit 80mg february last year it gently kicked in. Right as lockdown fell upon us. Typical! I did find myself a girlfriend though 'during lockdown' and waited till it was 'temporarily' over before meeting her. I'd say that's enough to say it was helping. Of course, that never worked out, how could it right?
7 weeks ago I bumped up to 90 and within days I began getting that benign yet releaving 'tingling' in my gut and chest, and thankfully my brain too!
Still a way to go, and whith all what's going on right now its tuff.
If I were you I'd do some research on dosing and take some hard evidence (with references!) to your doc and have a good sicere chat.

I wish you well. Ask any questions.
One quick tip for you - at higher doses, even at low doses at the beginning, urine retention can get problematic. But worry not. There's a drug called doxazosin that sorts it out very quickly. I'm currently taking 4 mg daily.
It's usually given for high blood pressure (handy when ur on an MAOI) and also for urine retention caused by an enlarged prostate.
https://www.niddk.nih.gov/health-information/urologic-diseases/urinary-retention/treatment
Alternatively, there's another old drug called... I can't remeber this minute lol. I'll come back when I remember. I have a consultation next week so If I don't remember I'll ask my doc. Cyproheptadine is sopposed to work too, but being a sedating antihistamine, its not very practicle.


Major Depression, Social Phobia, Agoraphobia, ADD.
Isocarboxazid, bupropion, amitriptyline, dexamfetamine, clonazepam, quetiapine + noots, supps and things.


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