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Re: for undopaminergic

Posted by undopaminergic on December 4, 2020, at 0:26:44

In reply to Re: for undopaminergic, posted by linkadge on December 3, 2020, at 16:04:37

> Thanks for sharing.

No problem.

> Also, have you found (if applicable) that reuptake inhibitors (like methlyphenidate, ethylhpenidate or cocaine) block the effect of amphetamines in any way?

I never tried that combination.

> I read that, in some paradigms (in mice at least) methlyphendiate can block some of the effects of amphetamines.

Cocaine does (in animals at least), so probably methylphenidate too. This is a direct result of their primary mechanism of action, to inhibit the DAT, which amphetamines (and PEA) depend upon to get taken into the nerve terminals where they can exert their neurotransmitter-releasing actions. It is probably dose dependent, and remember that higher (equivalent) doses are typically used in animal studies. I have often seen claims that in humans, the effects of cocaine plus amphetamines, are additive. While that seems to be an assumption (possibly erroneous), I think there is a possibility for it at lower cocaine doses.

On another note, the amphetamine-like stimulants have a more severe withdrawal. They made me feel drained of energy for months or years on end after quitting. It is important to note, however, that I used PEA long term. I think this was due to neurotoxicity comparable to that associated with methamphetamine, because it was worse than before I started the drug.

Meanwhile, for me, the reuptake inhibitor withdrawal lasted a night or at most a few days.





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