Posted by sigismund on November 24, 2020, at 12:31:58
In reply to Re: Methadone???Please help...esp users, posted by undopaminergic on November 24, 2020, at 1:21:20
The subjective effect, that which comes one hour after dosing, depends on the variability of the concentration minus your tolerance. My feeling is that the curve is flatter at higher doses, the half-life being effectively longer, and then most of the effect gone through tolerance.
Given my biochem 20 was a pretty good compromise.
It is not easy to give up the last little bit, from 10 to zero.
poster:sigismund
thread:1112649
URL: http://www.dr-bob.org/babble/20201025/msgs/1112664.html