Posted by undopaminergic on October 9, 2020, at 8:42:33
Of all drugs classified as "antidepressants", trimipramine (Surmontil) is by far the most helpful in my experience, and I've tried a lot (including 4 SSRIs!).
But how or why does it work?
Like many drugs, it is an antagonist at histamine H1, serotonin 5-HT2A, and muscarinic acetylcholine receptors. It is also an antagonist at alpha1-adrenergic and histamine-H2 receptors, and less so at dopamine-D2 sites.
I propose that the main beneficial mechanisms of action are the histamine-H2 and muscarinic blockade. The histamine-H2 seems to be the only unusual target.
-undopaminergic
poster:undopaminergic
thread:1112243
URL: http://www.dr-bob.org/babble/20200711/msgs/1112243.html