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How does trimipramine (Surmontil) work?

Posted by undopaminergic on October 9, 2020, at 8:42:33

Of all drugs classified as "antidepressants", trimipramine (Surmontil) is by far the most helpful in my experience, and I've tried a lot (including 4 SSRIs!).

But how or why does it work?

Like many drugs, it is an antagonist at histamine H1, serotonin 5-HT2A, and muscarinic acetylcholine receptors. It is also an antagonist at alpha1-adrenergic and histamine-H2 receptors, and less so at dopamine-D2 sites.

I propose that the main beneficial mechanisms of action are the histamine-H2 and muscarinic blockade. The histamine-H2 seems to be the only unusual target.





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