Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Effexor vs TCA+SSRI?

Posted by linkadge on September 12, 2020, at 5:57:22

In reply to Re: Effexor vs TCA+SSRI? linkadge, posted by PCB on September 10, 2020, at 20:45:00

Have you taken clomipramine? Was memory loss an issue? I took up to 75mg and only experienced a bit of morning haziness. I remember at the time I was first on sertraline (which wasn't cutting it) and was really depressed which caused me to fail a midterm exam in university (first time ever). We switched to clomipramine and the improvement was dramatic (although, in hindsight, the norepinephrine action may have improved ADHD like straterra is now - the sertraline wasn't helping in this regard). Long story short I aced the final exam and the prof replaced my midterm mark with the final mark (got an A+ in the course).

To answer your question, I know that (for me) nortriptyline + sertraline would work better than effexor. It's hard to say what would work better for you. I found nortriptyline + lithium worked better than SSRI + lithium. The latter seemed to amplify the serotonergic side effects (i.e. spacieness and apathy). On nortriptyline I started to develop some 'passions' again (i.e. deep interests in certain activities that gave me a reason to wake up in the morning). Now I'm on effexor (looking to switch off). It's ok, but I just feel kind of bla (although the straterra is improveing this). So my answer may be colored by the fact that the TCAs were treating undiagnosed ADHD.

Nevertheless, I do think that nortriptyline is a superior antidepressant. However, you could always start with effexor. I have never gone beyond 75mg (as it increased anxiety at that stage for me), but apparently it can become more effective at higher doses. Actually, I took effexor + nortriptyline too which, for depression, was very good. My sleep was a bit broken on that combo however. I replaced the nortriptyline with mirtazapine which improved sleep somewhat, but isn't as good for depression.

Linkadge


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:linkadge thread:1111991
URL: http://www.dr-bob.org/babble/20200711/msgs/1112017.html