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Re: Klonopin dementia or crippling panic?

Posted by linkadge on August 24, 2020, at 10:58:18

In reply to Re: Klonopin dementia or crippling panic? sigismund, posted by PCB on August 23, 2020, at 14:42:17

>So trimipramine has high anticholinergic effects >which is suppose to also be linked with dementia >and fragment the normal sleep cycle. So I guess we >are in trouble either way.

Trimipramine is one of the few depression meds that (according to studies I have read) that actually enhances (or, in the least, doesn't suppress) REM sleep. The anticholinergic effects could be an issue (perhaps) but it's hard to say. Take nortriptyline, for instance. It does have anticholinergic effects, but some recent studies show it also has marked neuroprotective effects and can block Alpha-synuclein (and reduces the development of Parkinson's pathologies) at least in mice. I'm not saying that the meds *don't* cause dementia (they may), but it's often patients with more severe risk factors that get prescribed these meds.

For example, milder anxiety, typically responds to SSRIs. More severe anxiety (which is, in itself, linked to dementia) usually needs stronger meds. Are these studies fully accounting for the severity of existing pathology, when determining the risk of the meds?

Linkadge


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URL: http://www.dr-bob.org/babble/20200711/msgs/1111857.html