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Re: Approaches to reverse damage of cocaine addiction

Posted by undopaminergic on August 21, 2020, at 3:27:40

In reply to Approaches to reverse damage of cocaine addiction, posted by amd on August 20, 2020, at 12:23:08

> I know that over time cocaine can have seriously negative effects on both the brain and body.

Cocaine does not have the neurotoxicity as amphetamines, but it does produce certain neural adaption that are largely negative in most cases. It can also cause brain damage by means of ischemia (due to vasospasm owing to noradrenaline reuptake inhibition).

With respect to addiction, the most important factor is the psyche. Specifically, an intense high leads to the formation of vivid memories of the high, and these memories will typically lead to craving.

> I am usually focused on the mental side of things. But what can one do to help recover the physical side -- particularly any heart or other cardiovascular damage done after years of cocaine abuse.
> Any pointers?

As far as the heart is concerned, both beta1-adrenergic blockers and beta2-agonists are beneficial.





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