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Re: MAOI frustrations

Posted by SLS on July 7, 2020, at 20:58:57

In reply to Re: MAOI frustrations, posted by rjlockhart37 on July 7, 2020, at 13:40:28

Just a quick correction, RJ.

Moclobemide is a reversible inhibitor of MAO-A. It is my impression that MAO-A is more important for depression than MAO-B.

Moblobemide does not often produce a lasting improvement. Most people find themselves escalating the dosage quickly to retain any benefit until they reach the maximum dosage of 1200 mg/day, and then there's nowhere to go. The only theoretical advantage to moclobemide is that its reversibility doesn't require one to follow a low-tyramine diet. But it is its reversibility that probably makes it such a crappy antidepressant.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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