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Re: Are TCAs more effective than SSRIs?

Posted by undopaminergic on June 7, 2020, at 3:44:34

In reply to Are TCAs more effective than SSRIs?, posted by Skeletor on June 6, 2020, at 20:07:00

> Are TCAs more effective than SSRIs? In your experience...

Absolutely. I've only used (and am using now) trimipramine (Surmontil), but it is the best drug classified as an antidepressant that I've ever tried.

> It would seem so, at least according to many studies... Gillman regularly mentions that his patients did substantially better on TCAs than on SSRIs (Sertraline might be an exception). Especially Amitriptyline, Clomipramine and Imipramine seem to be superior in effectivity. Is it wise to completely shun those very effective older antidepressants?

No, of course not. That would be just as stupid as avoiding MAOIs.





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