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Re: What are the overall best antipsychotics...?

Posted by undopaminergic on May 21, 2020, at 12:15:00

In reply to Re: What are the overall best antipsychotics...?, posted by Lamdage22 on May 21, 2020, at 11:09:12

> If you ask me, D2 antagonistic Antipsychotics do nothing for depression unless they somehow raise Dopamine at a low dose. Sulpiride, Amisulpiride. Maybe others.
>

Sulpiride and amisulpride preferentially block presynaptic dopamine autoreceptors, increasing dopamine release.

Flupenthixol is antidepressive, but I don't know what its mechanism of action might be.

> The abilifyish meds are different, because they sort of modulate Dopamine instead of killing it.
>

Yes, they are partial agonists. They antagonise when endogenous dopamine is high, and stimulate when dopamine is low.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20200511/msgs/1110283.html