Posted by undopaminergic on May 21, 2020, at 12:15:00
In reply to Re: What are the overall best antipsychotics...?, posted by Lamdage22 on May 21, 2020, at 11:09:12
> If you ask me, D2 antagonistic Antipsychotics do nothing for depression unless they somehow raise Dopamine at a low dose. Sulpiride, Amisulpiride. Maybe others.
>Sulpiride and amisulpride preferentially block presynaptic dopamine autoreceptors, increasing dopamine release.
Flupenthixol is antidepressive, but I don't know what its mechanism of action might be.
> The abilifyish meds are different, because they sort of modulate Dopamine instead of killing it.
>Yes, they are partial agonists. They antagonise when endogenous dopamine is high, and stimulate when dopamine is low.
-undopaminergic
poster:undopaminergic
thread:1109599
URL: http://www.dr-bob.org/babble/20200511/msgs/1110283.html