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Re: maoi poop out.

Posted by SLS on May 16, 2020, at 19:41:28

In reply to Re: maoi poop out., posted by undopaminergic on May 16, 2020, at 8:17:36

Hi, Rose.

What happened to you is cruel. I've heard of that happening frequently with Nardil, but not so much with Parnate. The term "drug-induced drug refractoriness" is sometimes used to described the phenomenon. RM Post first suggested it with the use of lithium in the 1990s.

In my experience, the dosage range for Parnate is 40-80 mg/day. For me, 80 mg/day is about right. Some people don't respond consistently to Parnate until they reach 120 mg/day. You won't find many doctors willing to use Parnate that way.

> I meant in combination with the MAOI. Someone here reported that the MAOI started working again after she added an antipsychotic (AP). I think the important action of APs in depression is their blockade of serotonin 5-HT2 receptors. With that in mind, you could also try mirtazapine or even cyproheptadine (an anti-histamine).
> Have you tried any serotonin 5-HT1A receptor agonists? Eg. buspirone and vortioxetine.
> -undopaminergic

Hi, UD.

Have you known anyone to combine a MAOI with mirtazapine? I've never seen it suggested. Is there any risk of a hypertensive reaction?

I have always needed to combine a MAOI with a tricyclic in order to see an improvement. I like nortriptyline better than desipramine. For me, nortriptyline has a distinct "mood brightening" effect that desipramine lacks. My only stable remission lasted for 9 months. I was taking Parnate + desipramine. My doctor decided that I should discontinue treatment because of the emergence of mania (bordering on psychosis). I relapsed 2 months later, and that combination never brought me to remission again.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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