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Re: How strong is Amitriptyline's sedative effect? linkadge

Posted by Skeletor on May 10, 2020, at 15:06:52

In reply to Re: How strong is Amitriptyline's sedative effect?, posted by linkadge on May 9, 2020, at 8:09:48

> It's fairly potent, but it can reduce over time (as it is also a potent SNRI). I found mirtazapine more sedating (but also less effective as an antidepressant).
> Linkadge

I am on Escitalopram 5mg, which is okay. That is 60% SERT occupancy. (I can't stand strong SRIs. Zoloft 50mg, 75mg and 100mg made me a zombie and anorectic)

Now I ve been thinking about adding something with 5HT2 antagonism. I once tried Mirtazapine, but that gave me RLS. Amitriptyline has 5HT2 antagonism and additionally it has some powerful NRI and antimuscarinic action. It seems to be quite a potent med, but sedation frightens me.




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