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Re: Parnate once a day: has anyone tried it?

Posted by gjg91 on April 18, 2020, at 16:55:05

In reply to Re: Parnate once a day: has anyone tried it?, posted by rjlockhart37 on April 18, 2020, at 12:58:44

Thank you, rjlockhart37, for taking the time to answer my question!

I had taken Parnate some years ago: I tried Nardil, Parnate, Nardil again (because it worked much better for me)... until the "worldwide shortage of the active ingredient" of Nardil forced me to take Parnate again, hahaha.

The first time, I divided doses like you said, even 4 times a day. The stimulant effect was difficult to sustain, and the result, strangely, was an intense sedation. Almost like the effect of a strong antipsychotic.

That's why I thought about "getting rid" from this acute effect in the morning, while keeping the real antidepressant effect of the med. In theory, the MAO inhibition should provide a sustained therapeutic effect, regardless of the molecule half-life.
It was clearly the case with Nardil, which worked like a charm all day long despite its short half-live... but it's true that both meds are very different!




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