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Re: Why do strong SRIs induce apathy, indifference?

Posted by undopaminergic on April 2, 2020, at 3:08:27

In reply to Why do strong SRIs induce apathy, indifference?, posted by Skeletor on April 1, 2020, at 13:37:30

> Why do strong SRIs (serotonin reuptake inhibitors) often cause / induce apathy, indifference and laziness? Maybe not in everyone, but it's one of the most common complaints. I regularly read about it on the internet. I myself was affected by it.
> My questions would be:
> 1.) What causes it?

My best guess is (indirect) agonism at the serotonin 5-HT2C receptor, which dampens down dopamine release.

> 2.) Were you affected?


> 3.) Did you successfully get rid of these specific side effects? If so, how so?

No, except if you count quitting the drug.

> 4.) Furher comments regarding that "phenomenon"?

I've read about it too. In certain cases SRIs can even cause symptoms of parkinsonism, such as cogwheel rigidity.





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