Posted by undopaminergic on April 2, 2020, at 3:08:27
In reply to Why do strong SRIs induce apathy, indifference?, posted by Skeletor on April 1, 2020, at 13:37:30
> Why do strong SRIs (serotonin reuptake inhibitors) often cause / induce apathy, indifference and laziness? Maybe not in everyone, but it's one of the most common complaints. I regularly read about it on the internet. I myself was affected by it.
>
> My questions would be:
> 1.) What causes it?My best guess is (indirect) agonism at the serotonin 5-HT2C receptor, which dampens down dopamine release.
> 2.) Were you affected?
Yes.
> 3.) Did you successfully get rid of these specific side effects? If so, how so?
>No, except if you count quitting the drug.
> 4.) Furher comments regarding that "phenomenon"?
I've read about it too. In certain cases SRIs can even cause symptoms of parkinsonism, such as cogwheel rigidity.
-undopaminergic
poster:undopaminergic
thread:1109340
URL: http://www.dr-bob.org/babble/20200303/msgs/1109354.html