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Re: Olanzapine

Posted by undopaminergic on March 16, 2020, at 4:18:59

In reply to Re: Olanzapine undopaminergic, posted by Jadde on March 15, 2020, at 18:27:12

>
> > I meant that some people get an enhanced response to their antidepressant regimen from an adjunctive antipsychotic (AP). It does not make much intuitive sense, but some APs are officially approved for this use, which suggests that it is not unsual for this to be better than placebo.
> >
> > -undopamnergic
> >
>
> Yes, it does not make much intuitive sense to me. Does it simply add an oomph of A/D on its own? Does it actually work synergistically with Nardil?
>

It's something about the combination. It think it is synergistic. It does not always work, but it may be worth trying. Lithium is an alternative in this role of augmentation.

> Or, does it work to prevent hypomania/mania,

Yes, depending on dose. I think some APs work better than others for this purpose.

> in which case does it also blunt the energetic qualities of Nardil?

Many APs are sedative, so yes.

> And finally, maybe it is prescribed to remedy side effects such as insomnia. I dont know.
>

That is pretty common, to use APs with an antihistamine action for insomnia. So other drugs than APs can be used, eg. doxepin, if they are antihistamines. Cyproheptadine (Periactin) seems to be a particularly good choice because it has been reported to improve the quality of sleep.

> As you can probably tell, I am very ignorant in regards to psych meds and how they work. I guess thats why Im here :)
>

I am still learning too.

> Thanks for your help!

You're welcome.

-undopaminergic


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