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Re: Lithium salts: carbonate vs. orotate

Posted by undopaminergic on February 21, 2020, at 12:33:42

In reply to Lithium salts: carbonate vs. orotate, posted by undopaminergic on February 20, 2020, at 10:58:26


"Dr. Hans Nieper of Germany has learned that lithium-orotate or lithium aspartate penetrate cells more effectively than lithium-carbonate so smaller doses can be used."


"To begin with the mineral orotates have the increased ability to enter cells. But, what do they do once theyre in? The beginning of the answer that question is that orotate salts are electrically neutral and relatively stable against dissociation, two properties crucial their ability to participate in intracellular mineral uptake and transport. The ability to dissociation (dissolve into component ions) in a solvent such as water, for example, dissociates into sodium and chloride ions. At physiological pH the orotate salts are much more stable than table salt and will not readily dissociate into free orotic acid plus a mineral ion."

"Free orotic acid (OA) itself is known to get into cells by simply leaking (diffusing) through cell membranes, rather than by being actively transported. But diffusion is a relatively inefficient process, which limits the amount of OA that can enter a cell. By contrast, uracila compound almost identical to OA, only minus the carboxylic acid groupis taken up efficiently by a transporter protein that binds to uracil molecules and drags them into the cell. This transporter appears to be specific for uracil or similar molecules which are uncharged, but not for uracils close cousin OA (which is negatively charged at body pH)."

"Bind the orotic acid with a mineral, however, and you end up with a stable electrically neutral salt. This property is just what is needed for OA along with its bound mineral to be taken up directly by the uracil transporter. At the same time, neutralizing the charge on OA makes the resulting complex more lipophilic or fat-loving than free OA; as a result, the stable orotate complex would be expected to diffuse more easily through the lipid membranes of cells. Essentially just such a mechanism was proposed by Nieper for enhancing the diffusion of mineral ions across cell membranes. Either wayvia enhanced diffusion or active transportcomplexing a mineral with orotate results in increased uptake of both components of the complex by cells."





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