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Re: Best med for complex-PTSD? undopaminergic

Posted by SLS on February 20, 2020, at 12:37:15

In reply to Re: Best med for complex-PTSD?, posted by undopaminergic on February 19, 2020, at 14:05:55

Hi, again.


> > That's great. What keeps you from using stimulants on a regular basis?
> I have indeed done so, during several periods of time. There are a few reasons I am not doing it now. a) the stimulants lost a lot of their effect, b) I'm seeking a lasting cure through psychological interventions, and c) current hospitalisation. Also, I don't have suicidal ideation at present.

Before I was properly diagnosed as having an affective disorder, I saw a few psychotherapists. I got virtually nothing from it - no reduction in depression or social and anxiety. In addition, they couldn't come close to reaching me as I was submerged below a tangle of involution.

Then I came across the book "Mood Swing" by Dr. Fieve. Because I was an ultra-rapid cycler at the time (8 days depression -> 3 days remission -> 8 days depression -> 3 days remission etc. Had my experience not matched the case histories described in the book, I would never had traveled to NYC Columbia-Presbyterian in 1982. There, I was diagnosed by Michael Liebowitz. When I learned that my mental disturbance was the result of biological dysfunction, I was very, very angry. Some people feel vindicated to learn this, but I was indignant that my depression and mental instability were beyond my power to work on and fix by myself. I was willing to work hard. Now, I felt teathered to a drug and incapable of sustaining a life worth living without that teather.

While I was waiting in the lobby for them to call me in for screening, I happened to notice a closed door to an office with a name plate reading, "Ronald R. Fieve", the man who wrote the book that saved my life. That was a strange coincidence that I had trouble believing.

Obviously, my brain has been entrained effectively to make compensatory adjustments to the changes effected by biological interventions (drugs). My brain likes the equilibrium it is now instructed to maintain - homeostasis.

It really sucks.

There is a drug called zuranolone (SAGE-217) that works as a positive allosteric modulator of the GABA-A receptor. It is an analogue of the intravenous-administered brexanolone by the same company that is now being used for post-partum depression, but is administered orally. It should have been approved by now. I don't know what's going on. Zuranolone has been reported to be effective for post-partum depression, major depressive disorder, and bipolar depression.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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