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Re: Choline is a sigma agonist

Posted by undopaminergic on January 1, 2020, at 14:48:36

In reply to Choline is a sigma agonist, posted by linkadge on December 31, 2019, at 18:07:46

> A new study reveals that choline itself is a sigma-1r agonist. Sigma agonists are known to improve cognition. Some of the alzheimers drugs (like ariciept) increase acetylcholine by slowing its breakdown AND act as sigma-1r agonists.

That's cool!

> However, a new finding suggests that choline itself is a sigma agonist. This means that it has the potential to improve cognition in two ways (by activating acetylcholine receptors and sigma receptors. Interestingly, parenteral choline intake is inversely associated with risk of schizophrenia as are sigma agonists like fluvoxamine. Perhaps the sigma receptor is a common target.
> Choline, for some, can cause depression. However, personally, I find it can ground me (during certain states).

As one would expect, it did nothing for me, neither good nor bad.

I believe I am predisposed to nocebo responses. The first time I got my hands on Concerta (methylphenidate as in Ritalin), I expected it to be the best thing since sliced bread as far as medications are concerned, but it did little for me and I quit it as I thought it was not worth the money. Many years later, I tried it again, expecting little, and then, it was so good that none of my days would be a complete failure as long as I took it.

Before that, too. The first (unless you count caffeine) psychopharmacological drug I tried was paroxetine (Seroxat), and I expected it to heal my burnout and depression. All it did was delay my orgasms and make me lie in bed all day.





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