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Re: Original MAOI vs TCA studies linkadge

Posted by undopaminergic on December 19, 2019, at 7:18:55

In reply to Re: Original MAOI vs TCA studies sigismund, posted by linkadge on December 18, 2019, at 16:24:38

> I would second that. I found trimipramine better than mirtazapine. On paper, they should be similar. Trimipramine had more of an anti-anhedonic effect. Not sure why.
>
> Linkadge

I wouldn't go so far as to call it anti-anhedonic, but I've noticed some anti-apathetic effects myself, especially at the start, with a dose of only 25 mg. I found it gave me more of a choice over whether to be active or rest.

I notice less with 50 mg, which I've been on for months now.

I think these effects may be related to the fact that it is a histamine H2-receptor antagonist. See the studies of famotidine in schizophrenia.

-undopaminergic


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