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Re: Venlafaxine vs. Duloxetine more stimulating? linkadge

Posted by undopaminergic on December 9, 2019, at 10:34:23

In reply to Re: Venlafaxine vs. Duloxetine more stimulating? beckett2, posted by linkadge on September 24, 2019, at 18:29:44

> I have not taken Cymbalta. I was possibly considering as being more noradrenergic than Effexor (at least on paper).
> Linkadge

One stategy is to adjust serotonin and noradrenaline reuptake inhibitions independently of each other.

Eg. titrate sertraline (or escitalopram, etc.) to find the most suitable dose. Do the same with reboxetine (or atomoxetine or nortriptyline).

Warning, the -oxetines may cause depersonalisation. It is known that atomoxetine is a kappa-opioid agonist. However, that may be true of reboxetine as well, because several people, including myself, have experienced depersonalisation from the use of this drug. In my case, this symptom did not reverse upon cessation of reboxetine. I still suffer from it more than 15 years later. Thus, your safest bet is nortriptyline, but this drug has other side effects (eg. antihistamine) and it is less noradrenaline-selective.





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