Posted by rjlockhart37 on October 23, 2019, at 0:43:01
i've been doing some extend reseaerch on barbiturates for anxiety and sleep, and most know the reason there not used much anymore is because their easy to over dose on, and the withdrawls are worse than benzos. But looking through the ads, butabarbutal was a main anxiety barbiturate medication, phenobarbital was long acting, and sedating, also used for anxiety. Mostly the rest like secobarbital and amobarbital are for sleep. There more sedating, and the difference is benzos increase the frequency of choride ion intake where GABA moduates.
barbiturates increase the duration, rather than frequency. Which means...benzos have a cieling effect where freqeuncy will only let certain amount of ions to go into. Barbirutates hold the duration and keep it open, that's why they give more of a peaceful, sedation. Benzos are more relax and relief. And also having a long duration that's why it's easy to over dose, because prolonged duation of GABA-operated chloride channels. It can flood the brain to where it goes lose respitory, coma, or death. They usually use pentobarbital in lethal injection.
It's just htere not used naymore i guess because of their history of drug abuse and deaths related to over dose. There much easier to over dose on than benzodiapines. Not too many people today take barbiturates for anxiety, only phenobarbital would be a choice, and it's usually not preferable.
anyone ever thought or had thoughts about barbiturate benefits?
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poster:rjlockhart37
thread:1106532
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