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Re: Ketamine treatment for TRD while on an MAOI safe?

Posted by linkadge on August 22, 2019, at 15:05:29

In reply to Ketamine treatment for TRD while on an MAOI safe?, posted by dbser on August 22, 2019, at 14:00:31

Hey,

So, I did a little PubMed searching. I couldn't find any case reports of problems with ketamine + MAOI. However, there probably isn't a lot of clinical experience with the combination since, up to recently, ketamine wasn't considered an antidepressant and so was likely avoided in patients on MAOIs.

I did find a few case reports of the combination being used without incident:

Possibly Safe:

https://www.ncbi.nlm.nih.gov/pubmed/26302763
https://www.ncbi.nlm.nih.gov/pubmed/2271195
https://www.ncbi.nlm.nih.gov/pubmed/6849728

Ketamine Inhibition of Serotonin Transporter

https://www.ncbi.nlm.nih.gov/pubmed/6460944


This being said, it does still inhibit serotonin reuptake and so any concurrent use should be done under supervision AND likely starting at a low dose.

Linkadge

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