Posted by linkadge on August 19, 2019, at 8:13:29
In reply to Help Me with My Med Regimen! Please/Anyone, posted by PCB on August 19, 2019, at 6:34:40
Hey,
I read over your list. A few things that pop out to me...
1) nardil + coffee seems to work fairly consistently with you. Keeping some nardil on board may therefore be helpful / necessary?
2) A short acting, low potency antipsychotic can temporarily block serotonin and dopamine and help to restore sleep cycles. You may look at meds like say low dose Seroquel or perphenazine. They have the added bonus of, by blocking 5-ht2a, they increase melatonin release which may help you adjust to shift changes. For me, 25-50mg of Seroquel completely reversed parnate insomnia and was fairly tolerable overall. The problem with MAOIs is that they bombard your brain 24/7 with serotonin, dopamine and norepinephrine. This can lead to insomnia (mice lacking MAO have severe sleep abnormalities). Lack of REM sleep can cause disorders that resemble bipolar or schizophrenia.
3) Trimipramine and nortriptyline can be combined with MAOIs as they are generally devoid of serotonin reuptake inhibition. The former is very good for sleep.
4) If selegeline worked to some extent, it may be worth revisiting. It has the benefit of fewer interactions than older MAOIs.
5) other cheap supplements (like zinc, folic acid, vitamin D and/or b12) can augment many psychiatric medications
6) abilify can probably be combined with MAOIs and has mood stabilizing qualities.
7) dopamine agonists like Mirapex have antidepressant properties and can likely be combined with MAOIs.
8) PEA (phenylethylamine) is an endogenous amphetamine-like substance with antidepressant qualities. It is broken down in the body by MAO-B. It is linked to the antidepressant effects of exercise. Studies have used it in combination with
selegeline (see below). It is present in chocolate, but can be purchased as a supplement. I can't say whether it is safe to combine with traditional MAOIs, but something to consider:https://www.ncbi.nlm.nih.gov/pubmed/9081552
What are your most prominent symptoms right now? Depression, insomnia, anhedonia, energy..?
Linkadge
poster:linkadge
thread:1105790
URL: http://www.dr-bob.org/babble/20190728/msgs/1105792.html